Sharing the Discovery & Functional Optimization of Optimer-drug Conjugates for the Targeting of Antisense Oligonucleotides
Time: 2:00 pm
day: Day One
Details:
- Optimer binders are oligonucleotide-based affinity ligands that can operate as next-generation delivery vehicles for a diverse range of therapeutic cargo
- Discovery, conjugation, and optimization processes detail the development of functional Optimer delivery vehicles to target an ASO payload to the kidney
- Review how developed Optimer delivery vehicles show enhanced delivery and consequent knockdown of expression in preclinical in vitro models, with the necessary biodistribution
